Data were collected as part of the evaluation of the SAAF family-based preventive intervention study. The data reported in this paper were collected from families randomly assigned to the prevention or control condition. Risk behaviors were assessed when the youths were 11 (pretest), 12 (posttest), 13 (follow-up) and 14 (long-term follow-up) years old. Data on intervention-targeted parenting practices were obtained at the posttest assessment; genetic data were obtained 2 years after the long-term follow-up assessment. All youths with at least one 7-repeat allele or two 4-repeat alleles who also had data for 5HTT (N = 337) were included in the analyses. We provide here a brief description of subject recruitment and enrollment, intervention implementation and fidelity, and data collection procedures; these procedures are described extensively in earlier reports on SAAF’s efficacy (Brody et al., 2004; Brody, Murry, Gerrard et al., 2006; Brody, Murry, Kogan et al., 2006).