NOS1 has been associated with impulsive and aggressive behavior and ADHD (Reif et al. 2009). Association has also been noted with Alzheimer’s disease (Galimberti et al. 2008) and schizophrenia, as well as with related neuropsychological performance (Reif et al. 2006).Table 2Association findings from quantitative GWAS by Lasky-Su et al. (2008b) with P values <10−5, including genes in or near which the association finding is present as well information regarding the role of the gene and its possible involvement in psychiatric disordersPhenotypeSNPGenetic model P valueChrBase pairsPositionGene functiona Additional remarksFBAT-PC all symptoms rs6565113 AdditiveNA# 1681665146Intron of CDH13Encodes cadherin 13, a member of the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein. This particular cadherin is a putative mediator of cell–cell interaction in the heart and may act as a negative regulator of neural cell growth. Lies within the only significant linkage region for ADHD as determined in met-analysis (Zhou et al. 2008c). Has earlier shown association with metamphetamine dependence in GWAS (Uhl et al. 2008a). Gene is also found in GWAS in schizophrenia with P values of 10−4 (Sullivan et al. 2008) and shows CNVs potentially related to autism (Christian et al. 2008)Gene also shows association with adult
