on the number of SNPs analyzed, and the threshold is approximately 5 × 10−8 for the GWA-chips that are used currently (660,000–1,000,000 SNPs) (Dudbridge and Gusnanto, 2008; Hoggart et al., 2008; Pe'er et al., 2008). This correction method is very conservative since the association findings of each SNP are considered to be independent, and the haplotype structure of the genome is not taken into account. Although conservative correction for multiple testing reduces the risk of false positive findings, it hampers the detection of true association signals with small effects on the risk for schizophrenia.
