the phase transition from dark to light (when mice normally sleep), the CTRL mice had more continuous, uninterrupted patterns of sleep, with an average sleep bout of 511.5 ± 36.4 seconds (8.53 minutes), whereas SCZ mice were asleep for 306.2 ± 43.7 seconds, or 5.1 minutes per bout (p<0.01 by 2-way ANOVA, with Bonferroni post hoc t tests). The shorter average periods of inactivity manifested by SCZ hGPC mice during the normal daytime transition to sleep suggests that SCZ hGPC chimerization disrupted normal daytime sleep patterns, while increasing night-time activity. Together, these results suggest that SCZ glial chimerization was sufficient to yield heightened anxiety and fear in engrafted recipients, as well as disease-associated deficits in socialization, cognition, and sleep patterning, all features associated with human schizophrenia.
