parental risks, are associated with higher OXTR methylation at birth. It is unclear whether this association is causal (e.g., a direct impact of parental risks on fetal development) or correlational (e.g., reflecting genetic confounding; 48, 49). Third, OXTR methylation in this group was found to have greater temporal stability (vs. INT+) from birth to age 9. The finding that OXTR methylation is more stable and associated with CU exclusively in INT− raises the question of whether this group may respond differently to interventions, such as intranasal oxytocin administration, compared to the INT+.
