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Chunk #29 — Results — KCNJ6 haplotype alters morphology and membrane excitability

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Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons.
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properties (i.e., KCl-induced activity). Furthermore, not only did the spike rate increase per cell (bar plots, Spikes/ROI/min), but we also observed increases in the proportion of cells in a field that responded (pie plots). These results not only confirm findings of differences in excitability, but also demonstrate that the difference in the AF iNs is found in not only individual cell activity but also in the frequency of detecting active cells within a population.