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Chunk #30 — Results — Ethanol exposure eliminates differences in properties affected by KCNJ6 haplotype

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Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons.
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Analysis of KCNJ6 mRNA expression in selected neurons (Fig. 1C) not only detected decreased basal levels in the AF group, but also demonstrated increased expression following ethanol treatment. This predicts that increasing GIRK2 expression in the AF group following ethanol treatment would eliminate differences from the UN group in morphology, expression, and physiology.