We estimated polygenic scores (PGS), which are aggregate measures of the number of risk alleles individuals carry weighted by effect sizes from GWAS summary statistics, for a variety of psychiatric and substance use phenotypes. We included PGS derived from recent GWAS of (1) alcohol use disorders (AUD) (Zhou et al., 2020), (2) depression (DEP, 23andMe excluded) (Levey et al., 2021), (3) post-traumatic stress disorder (PTSD) (Nievergelt et al., 2019), (4) bipolar disorders (BIP) (Bigdeli et al., 2020; Mullins et al., 2021), (5) schizophrenia (SCZ) (Bigdeli et al., 2020; Trubetskoy et al., 2022) (6) smoking initiation (SMOK, as a proxy for externalizing risk) (Karlsson Linnér et al., 2021; Saunders et al., 2022) and (7) suicide attempt (SUI) (Docherty et al., 2023). For AUD and BIP, we meta-analyzed published GWAS results with corresponding results from FinnGen (release 9) (Kurki et al., 2023). We focus on these PGS specifically because: 1) these disorders are phenotypically correlated with suicide attempt, and 2) they contain GWAS results for both European-like and African-like groupings. For GWAS that originally included COGA in the discovery sample, we obtained summary statistics with COGA removed.
