Meta-analyses were conducted using the R library rmeta applying a fixed effect model. In the first meta-analysis, three genetic models were tested, the two opposite carrier models and an allelic model resulting in a number of 2.02 effective tests as estimated from 10,000 permutations. In the second meta-analysis (combining the results of the first meta-analysis with the data from the RADIANT/WTCCC2 sample) only the recessive model for rs1545843 was tested. The adjustment for the two tests performed in RADIANT/WTCCC2 was done by adjusting the standard error of the estimate accordingly.
