Variables known to be correlated with alcohol consumption, GMV, or both were included as covariates in all analyses: age (36–38), sex (37–40), ethnicity (40,41), socioeconomic status (SES) (36–40), early-life and recent-life stress (42–44), and intracranial volume. In adult samples (DNS, HCP), the presence of any nonsubstance Axis I DSM-IV psychiatric disorder was included as a covariate. As the TAOS sample was composed of children and adolescents enriched for a family history of depression, Tanner stage and depressive symptoms were included as covariates. Supplement 1 contains additional details, including consideration of nicotine and cannabis use.
