As states continue to proceed with legalization for both medical and recreational use, a number of public health issues have become increasingly relevant, including the effects of acute marijuana intoxication on driving abilities, unintentional ingestion of marijuana products by children, the relationship between marijuana and opioid use, and whether there will be an increase in health problems related to marijuana use, such as dependence/addiction, psychosis, and pulmonary problems. In light of the rapidly shifting legal landscape, more research is urgently needed to better understand the impact of legalization on public health.