Marijuana Legalization: Impact on Physicians and Public Health.
paper
Cited
Public
- Authors
- Wilkinson, Samuel T; Yarnell, Stephanie; Radhakrishnan, Rajiv; Ball, Samuel A; D'Souza, Deepak Cyril
- Year
- 2016
- Journal
- Annual review of medicine
- PMID
- 26515984
- DOI
- 10.1146/annurev-med-050214-013454
- PMCID
- PMC4900958
Marijuana is becoming legal in an increasing number of states for both medical and recreational use. Considerable controversy exists regarding the public health impact of these changes. The evidence for the legitimate medical use of marijuana or cannabinoids is limited to a few indications, notably HIV/AIDS cachexia, nausea/vomiting related to chemotherapy, neuropathic pain, and spasticity in multiple sclerosis. Although cannabinoids show therapeutic promise in other areas, robust clinical evidence is still lacking. The relationship between legalization and prevalence is still unknown. Although states where marijuana use is legal have higher rates of use than nonlegal states, these higher rates were generally found even prior to legalization. As states continue to proceed with legalization for both medical and recreational use, certain public health issues have become increasingly relevant, including the effects of acute marijuana intoxication on driving abilities, unintentional ingestion of marijuana products by children, the relationship between marijuana and opioid use, and whether there will be an increase in health problems related to marijuana use, such as dependence/addiction, psychosis, and pulmonary disorders. In light of this rapidly shifting legal landscape, more research is urgently needed to better understand the impact of legalization on public health.
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| Title | Year | PMID |
|---|---|---|
| Comparison of Parent, Peer, Psychiatric, and Cannabis Use Influences Across Stages of Offspring Alcohol Involvement: Evidence from the COGA Prospective Study. | 2017 | 28073157 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Associations between cannabis use, cannabis use motivations and past year polysubstance use among people living with HIV in Florida. | McNeely KV et al. | — | 2026 | → |
| Characteristics of trauma patients involved in motor vehicle collisions before and after legalization of medical marijuana in Pennsylvania. | Gimbel K et al. | — | 2026 | → |
| Chatbot Responses to Frequently Asked Questions About Cannabis and Its Use for Cancer Symptoms. | Kim MJ et al. | — | 2026 | → |
| Comparing random forest and elastic net models to predict substance use disorder transitions in participants with cannabis and stimulant use: Evidence from the All of Us cohort. | Zamora G et al. | — | 2026 | → |
| Talking About Cannabis: Perspectives of First Episode Psychosis Care Participants and Parents. | Lucksted A et al. | — | 2026 | → |
| The Highs and Lows of Fracture Fixation: Complications After Wrist Fracture Fixation for Users of Cannabis, Tobacco, or Neither Substance. | Kishan A et al. | — | 2026 | → |
| Assessing Responses to Cannabis Health Warnings Among Adults in U.S. Recreational States. | Massey ZB et al. | — | 2025 | → |
| A systematic review investigating prenatal cannabis and tobacco co-exposure: Impacts on neonatal, behavioral, cognitive and physiological outcomes. | Argote M et al. | — | 2025 | → |
| Cannabis and cannabinoids in dermatology: a systematic review and meta-analysis of quantitative outcomes. | Sermsaksasithorn P et al. | — | 2025 | → |
| Crack cocaine exposure leads to developmental alterations and mitochondrial dysfunction in the <i>Drosophila melanogaster</i> model. | Couto-Lima CA et al. | — | 2025 | → |
| Differential Effects of Cannabinoid Receptor 2 Agonists on HIV Replication and Inflammatory Activation in Monocyte-Derived Macrophages and Induced Pluripotent Stem Cell-Derived Microglia. | Starr A et al. | — | 2025 | → |
| Enablers, Barriers and Practical Applications of a Group-Based Pain Self-Management Program for Patients Receiving Medical Cannabis: A Qualitative Study of Patients and Clinicians. | Marom P et al. | — | 2025 | → |
| Increasing trends of cannabinoid hyperemesis syndrome in youth: The grass is not always greener. | Jack B et al. | — | 2025 | → |
| Marijuana policy and tribal communities in the United States. | Pedersen DE | — | 2025 | → |
| Prenatal Cannabis and Tobacco Co-Exposure and Its Association with Behavioural Outcomes in Middle Childhood: Co-exposition prénatale au cannabis et au tabac et son association avec les résultats comportementaux au cours de l'enfance intermédiaire. | Nadler E et al. | — | 2025 | → |
| Pre-Post Cannabis Legalization for Adult Use: A Trend Study of Two Cohorts of Young Adult Cannabis Users in Los Angeles. | Fedorova EV et al. | — | 2025 | → |
| The Role of Cannabis Policies and Perceptions of Penalties on the Association Between Adolescent Social Bonds and Cannabis Use. | Moscrop-Blake K et al. | — | 2025 | → |
| Assessing dental student knowledge on cannabis and demonstrating the need for cannabis education. | Kruger JS et al. | — | 2024 | → |
| A systematic review of cannabis health warning research. | Massey ZB et al. | — | 2024 | → |
| Cardiovascular and Respiratory Effects of Cannabis Use by Route of Administration: A Systematic Review. | Muheriwa-Matemba SR et al. | — | 2024 | → |
| Density of cannabis outlets <i>vs</i>. cannabis use behaviors and prevalent cannabis use disorder: findings from a nationally-representative survey. | Wichaidit W et al. | — | 2024 | → |
| Fear of COVID-19 and illicit drug use during COVID-19 pandemic in Japan: a case-control study. | Nitta K et al. | — | 2024 | → |
| Medical Cannabis Prescription Practices and Quality of Life in Thai Patients: A Nationwide Prospective Observational Cohort Study. | Stienrut P et al. | — | 2024 | → |
| "More stress, more addiction?" The relationship between stress and relapse of male individuals with drug addiction: A chain mediation model. | Guo H et al. | — | 2024 | → |
| Perceived Risks and Benefits and Frequency of Cannabis Use Among People with HIV in Different Legal Environments. | Laper S et al. | — | 2024 | → |
| Post-Ischemic Stroke Cardiovascular Risk Prevention and Management. | Guo Y et al. | — | 2024 | → |
| Presentation, Management, and Child Protective Service Reporting of Children Who Test Positive for Cannabis in an Emergency Room Setting. | Dubinin A et al. | — | 2024 | → |
| Structure-based identification of a G protein-biased allosteric modulator of cannabinoid receptor CB1. | Shen S et al. | — | 2024 | → |
| The Effects of Cannabis Use during Pregnancy on Low Birth Weight and Preterm Birth: A Systematic Review and Meta-analysis. | Baía I et al. | — | 2024 | → |
| Trends in marijuana and heavy alcohol use by cigarette smoking status among US adults: An analysis of the 2002-2019 NSDUH. | Rich JJ et al. | — | 2024 | → |
| Warning Labels as a Public Health Intervention: Effects and Challenges for Tobacco, Cannabis, and Opioid Medications. | Popova L et al. | — | 2024 | → |
| Cannabis and cannabinoids in dermatology: protocol for a systematic review and meta-analysis of quantitative outcomes. | Sermsaksasithorn P et al. | — | 2023 | → |
| Comparison of the Users' Attitudes Toward Cannabidiol on Social Media Platforms: Topic Modeling Study. | Li Y et al. | — | 2023 | → |
| Consumer perception, knowledge, and uses of cannabidiol. | Nguyen C et al. | — | 2023 | → |
| Cross-phenotype relationship between opioid use disorder and suicide attempts: new evidence from polygenic association and Mendelian randomization analyses. | Huang Y et al. | — | 2023 | → |
| Diagnosis and Management of Cyclic Vomiting Syndrome: A Critical Review. | Frazier R et al. | — | 2023 | → |
| Impact of early-life lead exposure on adult delta-9-tetrahydrocannabinol sensitivity in male and female C57BL6/J mice. | Garcy D et al. | — | 2023 | → |
| Medical Cannabis for Chronic Nonmalignant Pain Management. | Hameed M et al. | — | 2023 | → |
| Minor, Nonterpenoid Volatile Compounds Drive the Aroma Differences of Exotic <i>Cannabis</i>. | Oswald IWH et al. | — | 2023 | → |
| Predictors of illicit substance abuse/dependence during young adulthood: A machine learning approach. | Rakovski C et al. | — | 2023 | → |
| Somatic and terminal CB1 receptors are differentially coupled to voltage-gated sodium channels in neocortical neurons. | Steiger LJ et al. | — | 2023 | → |
| Cannabinol inhibits oxytosis/ferroptosis by directly targeting mitochondria independently of cannabinoid receptors. | Liang Z et al. | — | 2022 | → |
| Cannabis use is associated with prevalent coronary artery disease. | Skipina TM et al. | — | 2022 | → |
| CB1 receptor antagonist AM4113 reverts the effects of cannabidiol on cue and stress-induced reinstatement of cocaine-seeking behaviour in mice. | Luján MÁ et al. | — | 2022 | → |
| Influence of E-Cigarette and Cannabis Vaping on Orthodontically Induced Tooth Movement and Periodontal Health in Patients Undergoing Orthodontic Therapy. | Michelogiannakis D et al. | — | 2022 | → |
| Interacting binding insights and conformational consequences of the differential activity of cannabidiol with two endocannabinoid-activated G-protein-coupled receptors. | Dávila EM et al. | — | 2022 | → |
| Michigan Marijuana Legalization: Correlations Among Cannabis Use, Mental Health, and Other Factors. | Pawl C et al. | — | 2022 | → |
| Prevalence of Cannabis Use and Cannabis Route of Administration among Massachusetts Adults in Buprenorphine Treatment for Opioid Use Disorder. | Streck JM et al. | — | 2022 | → |
| Relation of Cannabis Use to Elevated Atherosclerotic Cardiovascular Disease Risk Score. | Skipina TM et al. | — | 2022 | → |
| Somatic and terminal CB1 receptors are differentially coupled to voltage-gated sodium channels in neocortical neurons | Steiger L et al. | — | 2022 | — |
| The Association of Cannabis Use and Cigarette Smoking with Psychological Distress Among Adults in California. | Wang N et al. | — | 2022 | → |
| The Potential Impact of Legalization of Recreational Cannabis among Current Users: A Qualitative Inquiry. | Benz MB et al. | — | 2022 | → |
| Thromboembolic Outcomes in Tetrahydrocannabinol-Positive Trauma Patients With Traumatic Brain Injury. | Ali A et al. | — | 2022 | → |
| TRPV1: A Common Denominator Mediating Antinociceptive and Antiemetic Effects of Cannabinoids. | Louis-Gray K et al. | — | 2022 | → |
| Understanding <i>Cannabis sativa</i> L.: Current Status of Propagation, Use, Legalization, and Haploid-Inducer-Mediated Genetic Engineering. | Simiyu DC et al. | — | 2022 | → |
| Cardiovascular Effects of Medical Marijuana: A Systematic Review. | Pasha AK et al. | — | 2021 | → |
| Cerebellar thickness changes associated with heavy cannabis use: A 3-year longitudinal study. | Wang Y et al. | — | 2021 | → |
| Changes in Emergency Department Encounters for Vomiting After Cannabis Legalization in Colorado. | Wang GS et al. | — | 2021 | → |
| Demand curve analysis of marijuana use among persons living with HIV. | Greenwald MK et al. | — | 2021 | → |
| Efficacy of Cannabidiol for Δ-9-Tetrahydrocannabinol-Induced Psychotic Symptoms, Schizophrenia, and Cannabis Use Disorders: A Narrative Review. | Bartoli F et al. | — | 2021 | → |
| How medical are states' medical cannabis policies?: Proposing a standardized scale. | Richard EL et al. | — | 2021 | → |
| Identification of a New Family of Prenylated Volatile Sulfur Compounds in <i>Cannabis</i> Revealed by Comprehensive Two-Dimensional Gas Chromatography. | Oswald IWH et al. | — | 2021 | → |
| Non-medical Use of Prescription Stimulants Among College Students: Non-oral Routes of Administration, Risk Factors, Motivations, and Pathways. | Butler SF et al. | — | 2021 | → |
| Outcomes in patients with acute myocardial infarction and history of illicit drug use: a French nationwide analysis. | Ma I et al. | — | 2021 | → |
| Prevalence and Correlates of Cannabis Use in Massachusetts after Cannabis Legalization and before Retail Sales. | Evans EA et al. | — | 2021 | → |
| Recent Trends in Cannabis Use in Older Americans. | Maxwell CJ et al. | — | 2021 | → |
| Reelin deficiency contributes to long-term behavioral abnormalities induced by chronic adolescent exposure to Δ9-tetrahydrocannabinol in mice. | Iemolo A et al. | — | 2021 | → |
| Societal issues and policy implications related to the use of cannabinoids, cannabis, and cannabis-based medicines for pain management. | Haroutounian S et al. | — | 2021 | → |
| A nationwide survey of pharmacy students' knowledge and perceptions regarding medical cannabis. | Moeller KE et al. | — | 2020 | → |
| A Survey Exploring the Relationship Between Cannabis Use Characteristics and Sexual Function in Men. | Bhambhvani HP et al. | — | 2020 | → |
| A systematic review of the effectiveness of employer-led interventions for drug misuse. | Akanbi MO et al. | — | 2020 | → |
| Cannabinoid Use in Musculoskeletal Illness: a Review of the Current Evidence. | O'Connor CM et al. | — | 2020 | → |
| Cannabis use is associated with monocyte activation (sCD163) in patients admitted for alcohol use disorder treatment. | Fuster D et al. | — | 2020 | → |
| Marijuana sources in a medical marijuana environment: dynamics in access and use among a cohort of young adults in Los Angeles, California. | Reed M et al. | — | 2020 | → |
| Marijuana Use in Patients With Cardiovascular Disease: JACC Review Topic of the Week. | DeFilippis EM et al. | — | 2020 | → |
| Medical cannabis for chronic pain: can it make a difference in pain management? | Maharajan MK et al. | — | 2020 | → |
| Periodontal Conditions and Whole Salivary IL-17A and -23 Levels among Young Adult <i>Cannabis sativa</i> (Marijuana)-Smokers, Heavy Cigarette-Smokers and Non-Smokers. | Javed F et al. | — | 2020 | → |
| Problem Drinking and Marijuana Use as Risks for Unidirectional and Bidirectional Partner Violence. | Cunradi CB et al. | — | 2020 | → |
| The impact of cannabis access laws on opioid prescribing. | McMichael BJ et al. | — | 2020 | → |
| The positive and negative cardiovascular effects of cannabis. | Adamson M et al. | — | 2020 | → |
| Topical Capsaicin for Treating Cannabinoid Hyperemesis Syndrome. | Aziz A et al. | — | 2020 | → |
| Urinary Acrylonitrile Metabolite Concentrations Before and after Smoked, Vaporized, and Oral Cannabis in Frequent and Occasional Cannabis Users. | Ashley DL et al. | — | 2020 | → |
| Association between cannabis laws and opioid prescriptions among privately insured adults in the US. | Raji MA et al. | — | 2019 | → |
| Association of Marijuana Use with Changes in Cognitive Processing Speed and Flexibility for 17 Years in HIV-Seropositive and HIV-Seronegative Men. | Okafor CN et al. | — | 2019 | → |
| Cannabinoids as a Potential New and Novel Treatment for Melanoma: A Pilot Study in a Murine Model. | Simmerman E et al. | — | 2019 | → |
| Cerebellar alterations in cannabis users: A systematic review. | Blithikioti C et al. | — | 2019 | → |
| Fatal crashes in the 5 years after recreational marijuana legalization in Colorado and Washington. | Aydelotte JD et al. | — | 2019 | → |
| Prenatal cannabinoid exposure and altered neurotransmission. | Pinky PD et al. | — | 2019 | → |
| Radiation Therapy Pain Management: Prevalence of Symptoms and Effectiveness of Treatment Options. | Lamba N et al. | — | 2019 | → |
| Risks of harm with cannabinoids, cannabis, and cannabis-based medicine for pain management relevant to patients receiving pain treatment: protocol for an overview of systematic reviews. | Gilron I et al. | — | 2019 | → |
| State marijuana laws and opioid overdose mortality. | Chihuri S et al. | — | 2019 | → |
| The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study. | Di Forti M et al. | — | 2019 | → |
| The Implementation of Marijuana Legalization in New York. | Mitra S et al. | — | 2019 | → |
| Association of Medical and Adult-Use Marijuana Laws With Opioid Prescribing for Medicaid Enrollees. | Wen H et al. | — | 2018 | → |
| Cannabinoid Hyperemesis Syndrome: Pathophysiology and Treatment in the Emergency Department. | Richards JR | — | 2018 | → |
| Cannabinoid hyperemesis syndrome: potential mechanisms for the benefit of capsaicin and hot water hydrotherapy in treatment. | Richards JR et al. | — | 2018 | → |
| Co-use of tobacco and marijuana during pregnancy: Pathways to externalizing behavior problems in early childhood. | Godleski SA et al. | — | 2018 | → |
| Efficacy, tolerability and safety of cannabis-based medicines for chronic pain management - An overview of systematic reviews. | Häuser W et al. | — | 2018 | → |
| Emerging Topics and Innovative Methodologies in Cannabis Research. | Albright VA et al. | — | 2018 | → |
| Framing marijuana: How U.S. newspapers frame marijuana legalization stories (1995-2014). | Kim H et al. | — | 2018 | → |
| Medical cannabis: An oxymoron? Physicians' perceptions of medical cannabis. | Zolotov Y et al. | — | 2018 | → |
| Medical marijuana in pediatric oncology: A review of the evidence and implications for practice. | Ananth P et al. | — | 2018 | → |
| Non-medical Cannabis Self-Exposure as a Dimensional Predictor of Opioid Dependence Diagnosis: A Propensity Score Matched Analysis. | Butelman ER et al. | — | 2018 | → |
| Past-month cannabis use among U.S. individuals from 2002-2015: An age-period-cohort analysis. | Chawla D et al. | — | 2018 | → |
| Primary Causes of Hospitalizations and Procedures, Predictors of In-hospital Mortality, and Trends in Cardiovascular and Cerebrovascular Events Among Recreational Marijuana Users: A Five-year Nationwide Inpatient Assessment in the United States. | Desai R et al. | — | 2018 | → |
| Regular Marijuana Use is Associated with Poor Viral Suppression in HIV-Infected Adolescents and Young Adults. | Thompson AB et al. | — | 2018 | → |
| The association of cannabis use on inpatient psychiatric hospital outcomes. | Rylander M et al. | — | 2018 | → |
| The dose-dependent psychomotor effects of intravenous delta-9-tetrahydrocannabinol (Δ<sup>9</sup>-THC) in humans. | Boggs DL et al. | — | 2018 | → |
| Unique treatment potential of cannabidiol for the prevention of relapse to drug use: preclinical proof of principle. | Gonzalez-Cuevas G et al. | — | 2018 | → |
| Weighing the Benefits and Risks of Medical Marijuana Use: A Brief Review. | Karst A | — | 2018 | → |
| A 10-year review of cannabis exposure in children under 3-years of age: do we need a more global approach? | Claudet I et al. | — | 2017 | → |
| A Greener Oregon: Acute Inpatient Delirium. | Fine C et al. | — | 2017 | → |
| Cannabinoid hyperemesis syndrome: A disorder of the HPA axis and sympathetic nervous system? | Richards JR | — | 2017 | → |
| Cannabis as Secondary Drug Is Not Associated With a Greater Risk of Death in Patients With Opiate, Cocaine, or Alcohol Dependence. | Fuster D et al. | — | 2017 | → |
| Comparison of Parent, Peer, Psychiatric, and Cannabis Use Influences Across Stages of Offspring Alcohol Involvement: Evidence from the COGA Prospective Study. | Bucholz KK et al. | — | 2017 | → |
| Health and Public Policy to Facilitate Effective Prevention and Treatment of Substance Use Disorders Involving Illicit and Prescription Drugs: An American College of Physicians Position Paper. | Crowley R et al. | — | 2017 | → |
| Marijuana practices and patterns of use among young adult medical marijuana patients and non-patient marijuana users. | Lankenau SE et al. | — | 2017 | → |
| Monitoring quality and coverage of harm reduction services for people who use drugs: a consensus study. | Wiessing L et al. | — | 2017 | → |
| Pharmacologic Implications of Marijuana Use During Pregnancy. | Fantasia HC | — | 2017 | → |
| Pharmacologic Treatment of Cannabinoid Hyperemesis Syndrome: A Systematic Review. | Richards JR et al. | — | 2017 | → |
| Prevalence and correlates of marijuana use among HIV-seropositive and seronegative men in the Multicenter AIDS Cohort Study (MACS), 1984-2013. | Okafor CN et al. | — | 2017 | → |
| Prevalence and correlates of sleep-related problems in adults receiving medical cannabis for chronic pain. | Cranford JA et al. | — | 2017 | → |
| Propranolol Treatment of Cannabinoid Hyperemesis Syndrome: A Case Report. | Richards JR et al. | — | 2017 | → |
| Public perceptions of arguments supporting and opposing recreational marijuana legalization. | McGinty EE et al. | — | 2017 | → |
| Strokes are possible complications of cannabinoids use. | Wolff V et al. | — | 2017 | → |
| Tetrahydrocannabinol (THC) impairs encoding but not retrieval of verbal information. | Ranganathan M et al. | — | 2017 | → |
| Influence of legal status on the uptake of cannabis in young people. | Dirisu O et al. | — | 2016 | → |
| Marijuana use and its effects in pregnancy. | Chabarria KC et al. | — | 2016 | → |
| PTSD: from neurobiology to pharmacological treatments. | Kelmendi B et al. | — | 2016 | → |
| Small Molecule Detection in Saliva Facilitates Portable Tests of Marijuana Abuse. | Lee JR et al. | — | 2016 | → |
| The emerging public discourse on state legalization of marijuana for recreational use in the US: Analysis of news media coverage, 2010-2014. | McGinty EE et al. | — | 2016 | → |