Although marijuana remains illegal at the federal level, individual components of marijuana have been purified, tested, and approved by the FDA or similar regulatory agencies as medications for certain conditions. Oral THC is available as Dronabinol (Marinol®) and has been approved by the FDA for the treatment of HIV/AIDS cachexia (8, 9) and nausea/vomiting related to chemotherapy (10–12). Nabilone (Cesamet®) is an oral THC analog that is FDA-approved for the treatment of nausea/vomiting related to chemotherapy (13). Nabiximols (Sativex®) is an admixture of THC and CBD (approximately 1:1 ratio) in an oromucosal spray formulation; it has been approved by regulatory agencies in Canada and many countries throughout Europe to treat spasticity in multiple sclerosis (MS) (14, 15).
