Marijuana is typically consumed via smoking of joints or blunts (dried marijuana leaves rolled into cigarettes or cigars, respectively). More recently, in an effort to avoid the potentially harmful byproducts of burning marijuana, use of vaporizers has increased. Although this method of cannabis consumption may theoretically avoid the inhalation of toxins, rigorous clinical studies confirming its safety have not yet been done. When smoked or given intravenously, THC is rapidly absorbed, producing physical effects within minutes. Oral doses delay the onset of effects by 30–120 min, produce lower and irregular peak plasma levels compared to smoked THC, and prolong the action of the drug (7). The inhaled route allows for real-time dose titration, whereas delayed onset with oral consumption means that the individual cannot reduce the dose once effects, including negative ones, emerge. Hence, individuals who are not familiar with the effects of THC or other cannabinoids may become overwhelmed by the effects of oral consumption.
