Figure 1 shows all SNPs in bin A, and the only consistently associated sub-bins (p<0.01 in both Asians and African Americans). Bin A variants span six genes in the European ancestry population, the sub-bin tagged by rs16969968 in the Asian population spans three genes, and the sub-bin tagged by rs16969968 in the African American population spans only one gene (CHRNA5). Figure 2 provides a forest plot summary of the stratified meta-analyses for the bin/sub-bin tagged by rs16969968, the only consistent association for bin A, in all three populations. Each plot lists ORs for each contributing sample. The overall cross-population meta-analysis across all datasets gave an OR of 1.33 (95%C.I.=1.25–1.42, p=1.1×10−17).
