We detected a strong association between the dichotomous phenotype of heavy smoking versus light smoking and bin A in European ancestry data (OR=1.31, 95% C.I.=1.22–1.40, p=1.3×10−14). The only sub-bin showing consistent association with heavy smoking across the other two populations is tagged by rs16969968 (Asian population: OR=1.64, 95%C.I.=1.15–2.32, p=5.8×10−3; African American population: OR=1.62, 95% C.I.=1.21–2.17, p=1.1×10−3). As noted in the Methods, because the probability of any particular test resulting in a p<0.01 in both populations by chance alone would be 0.0001, this result of consistent association in both populations remained significant after Bonferroni correction.
