No significant gene-based tests were observed after correcting for the number of valid gene-based test results, which varied by population and dependence outcome. The top ranked gene (P = 4.5 × 10−6) in gene based tests was calcium voltage-gated channel subunit alpha1 B (CACNA1B) in the EA CD analysis. One gene set (membrane depolarization) showed a significant enrichment, with six of 83 genes, including CACNA1B, showing nominally significant gene based test results after Bonferroni correction (P = 0.04) for CD in EAs.
