In the discovery sample, we identified tone region containing variants associated with TD at a GWS level (P < 5 × 10−8) in the gene family with sequence similarity 78-member B (FAM78B) on chromosome 1 (rs61835088, P = 2.96 × 10−8) for CD in the combined EA and AA sample. Each copy of minor (C) alleles at rs61835088 was associated with 0.57 fewer years between first use and CD diagnosis among those who converted. The Manhattan plots for CD and OD in Yale-Penn AAs and EAs are shown in Supplemental Figure 3. There was no evidence for inflation of the test statistics for either substance in either EAs or AAs (Supplemental Figure 4).
