Drug annotation to date centers on cases in which a drug binds a protein (normal or genetic variant) and alters the protein’s default function, thereby regulating it. The Reactome data model can accommodate more diverse and complicated drug–target interactions, and can likewise accommodate the other stages of a drug’s life cycle in the body in which it is taken up, transported to a target site, activated, then inactivated and excreted. These extensions are the focus of work now getting underway.
