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Chunk #46 — Discussion — Zfhx1b regulates MGE cell-type generation

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Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons.
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The MGE also generates striatal interneurons. There are three subtypes of GABAergic striatal interneurons: PV+, nNos/NPY/Sst+ and CR+ (Tepper et al., 2010). The striatum also has cholinergic interneurons. The cholinergic population is marked and regulated by Gbx2, Islet1, and Lhx8 (Chen et al., 2010; Fragkouli et al., 2009), and the neurotrophin receptor TrkA (Sanchez-Ortiz et al., 2012).