paperKB
coga / coga-kb
Help
Sign in

Chunk #45 — Discussion — Zfhx1b regulates MGE cell-type generation

Source
Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons.
Embedded
yes

Text

The MGE generates multiple cell types, including GABAergic interneurons of the cortex and striatum, GABAergic projection neurons of the basal ganglia (e.g. GP), cholinergic neurons of the striatum and basal telencephalon and oligodendrocytes (Flandin et al., 2010; Petryniak et al., 2007; Xu et al., 2008). The MGE generates roughly 60% of all GABAergic cortical interneurons; these express PV, Sst, NPY and nNos (Gelman and Marín, 2010; Rudy et al., 2011).