We calculated PRS using PRS-CS for PAU (based on the EUR meta-analysis of PAU) in 131,500 individuals of EUR ancestry, and PRS for AUD (based on the AFR meta-analysis of AUD) in 27,494 individuals of AFR ancestry in four independent datasets (Vanderbilt University Medical Center’s Biobank, Mount Sinai (BioMe), Mass General Brigham Biobank (MGBB)84 and Penn Medicine Biobank (PMBB)85) from the PsycheMERGE Network86, followed by PheWAS. Details for each dataset are described below.
