Genetic correlations (rg) between PAU or AUD and traits of interest were estimated using LDSC. For EUR, we tested rg between PAU and 49 traits using published summary data and the EUR LD reference from the 1000 Genomes Project. The rg with P values <1.02 × 10−3 were considered significant. For AFR, we tested rg between AUD and 13 published traits in AFR using MVP in-sample LD (most of the analyzed AFR were from MVP) built from 1,000 randomly selected AFR individuals by cov-LDSC83. The rg with P values <3.85 × 10−3 (0.05/13) in AFR were considered as significant. For comparison, we also tested rg using 1000 Genomes AFR as the LD reference, which showed similar estimates.
