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Chunk #31 — Results — Genetic correlation analyses, and clustering solution

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Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry.
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We also identified a number of associations with UKB pain phenotypes, including positive genetic correlations with several pain ICD diagnoses (e.g., pain in throat, pelvic pain, rg range = [0.37–0.39], p < 8.22E−05), and prevalent pain conditions such as back and knee pain, and headaches (rg range = [0.21–0.42], p < 8.50E−03). As expected, we found positive genetic associations with chronic pain (rg = 0.42, p = 4.04E−17) and higher pain relief medication intake (e.g., Ibuprofen, rg = 0.49; p = 1.61E−10).