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Chunk #38 — 3. Results — 3.3. Correlations among the Top Significant Variables

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Random Forest Classification of Alcohol Use Disorder Using EEG Source Functional Connectivity, Neuropsychological Functioning, and Impulsivity Measures.
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Exploratory (descriptive) analysis of correlations among top significant variables are shown in Figure 7. BIS impulsivity scores showed significant positive correlations among themselves while showing significant negative correlations with two of the neuropsychological scores of the VST, viz., total correct scores during forward and backward trials, suggesting that those with high impulsivity showed poorer neuropsychological performance. FC variables showed significant positive correlations with BIS scores in several frequency bands: one theta connection [s5–s8 (L.IPL–R.PFC)], four beta connections [s2–s11 (R.PCC–L.PHG), s2–s7 (R.PCC–L.PFC), s2–s8 (R.PCC–R.PFC), and s7–s11 (L.PFC–L.PHG)], and two gamma connections [s4–s5 (R.ACC–L.IPL) and s11–s12 (L.PHG–R.PHG)]. Interestingly, all these connections showed hyperconnectivity in AUD subjects who also displayed increased impulsivity than the CTL group, suggesting that hyperconnectivity was associated with increased impulsivity and that both phenomena were observed in AUD individuals. Further, significant correlations across neuropsychological scores and four FC connections were observed. A bilateral prefrontal delta connection (L.PFC–R.PFC), which had hypoconnectivity in AUD, was negatively correlated with average time of memory processing, suggesting that higher FC score (hyperconnectivity) was associated less average time or faster memory processing, while AUD showed