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Chunk #39 — 3. Results — 3.3. Correlations among the Top Significant Variables

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Random Forest Classification of Alcohol Use Disorder Using EEG Source Functional Connectivity, Neuropsychological Functioning, and Impulsivity Measures.
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were observed. A bilateral prefrontal delta connection (L.PFC–R.PFC), which had hypoconnectivity in AUD, was negatively correlated with average time of memory processing, suggesting that higher FC score (hyperconnectivity) was associated less average time or faster memory processing, while AUD showed an opposite pattern of hypoconnectivity across prefrontal nodes and slower memory processing. In the other three connections, viz., R.LTC–R.PHG (delta), L.PFC–R.PHG (delta), L.LTC–L.PHG (alpha), which were hyperconnected in AUD, had significant negative correlations (p < 0.05) with with total correct score during forward trials, suggesting that hyperconnectivity in these connections was associated with poor memory performance, as observed in AUD individuals. Furthermore, FC connections had significant positive correlations with each other within the same frequency as well as across different frequencies (theta–alpha, alpha–beta, and beta–gamma band). A few other isolated correlations across FC connections of different frequencies were also observed: (i) positive correlation of the delta connection s2–s4 (R.PCC–R.ACC) with the alpha connections s7–s12 (L.PFC–R.PHG), s8–s9 (R.PFC–L.LTC), s9–s11 (L.LTC–L.PHG), and s10–s12 (R.LTC–R.PHG); (ii) positive correlation of the delta connections s2–s8 (R.PCC –R.PFC) and s6–s8 (R.IPL–R.PFC) with the beta connection s3–s12 (L.ACC–R.PHG); (iii) positive correlation of the theta connection s6–s11 (R.IPL–L.PHG) with the beta connections s7–s11 (L.PFC–L.PHG) and s8–s9 (R.PFC–L.LTC); and