Male CD1 mice were used for all experiments. Animals were 28 days old at the day of arrival and were kept on a 12L:12D cycle. Food and water was provided ad libitum. The experiments were carried out in accordance with European Communities Council Directive 86/609/EEC. All efforts were made to minimize animal suffering during the experiments. The protocols were approved by the committee for the Care and Use of Laboratory Animals of the Government of Upper Bavaria, Germany.