and hence neuronal excitability, in response to changes in intracellular calcium. Lies close to linkage region observed in several primary studies as well as a meta-analysis (Lewis et al. 2003). Gene is also found in GWAS in schizophrenia with p-values at 10−4 (Sullivan et al. 2008)Also shows nominal association (P < 0.05) in quantitative GWAS by Lasky-Su et al. (2008b)rs125055021.3035.62E-05491787046Intron of MGC48628Hypothetical gene/protein. Highly expressed in cerebellum, expression also in other parts of the brain and tissues. Gene is also found in GWAS in bipolar disorder with P values at 10−5 (Wellcome Trust Case Control Consortium 2007)Also shows nominal association (P < 0.05) in quantitative GWAS by Lasky-Su et al. (2008b)rs9227811.3155.62E-051558857636Intron of RORAEncodes a member of the NR1 subfamily of nuclear hormone receptors. It can bind either as a monomer or as a homodimer to hormone-response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Close to suggestive linkage region for ADHD (Faraone et al. 2008).
