metamphetamine dependence in GWAS (Uhl et al. 2008a). Gene is also found in GWAS in schizophrenia with P values at 10−4 (Sullivan et al. 2008) and shows CNVs potentially related to autism (Christian et al. 2008)Most significant finding in quantitative GWAS by Lasky-Su et al. (2008b). Also shows association with adult ADHD in the GWAS by Lesch et al. (2008)rs37823091.5275.53E-051226750663Intron of ITPR2Encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Expression in many tissues, including brain. ITPR2 is involved in glutamate-mediated neurotransmission, is one of the main regulators of intracellular calcium concentrations, and has an important role in apoptosis. Shows association with amyotrophic lateral sclerosis (ALS) in GWAS (van Es et al. 2007)Also shows nominal association (P < 0.05) in quantitative GWAS by Lasky-Su et al. (2008b)rs15416650.63385.60E-055170075495Intron of KCNIP1Encodes Kv channel interacting protein 1 isoform 2, a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), and may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Lies close to linkage region observed in several primary studies as well as a meta-analysis (Lewis et al. 2003). Gene is also found in GWAS in schizophrenia with p-values
