MAP3K5PEX7 encodes peroxisomal biogenesis factor 7, the cytosolic receptor for a set of peroxisomal matrix enzymes. MAP3K5 encodes a member of the MAPK pathway, that might be involved in apoptotic regulation in the brainAlso shows nominal association (P < 0.05) in quantitative GWAS by Lasky-Su et al. (2008b)rs127727370.72464.96E-0510116731491Within 6 kb downstream of TRUB1Encodes TruB pseudouridine (psi) synthase homolog 1, expressed in many tissues, including brain, which may be responsible for synthesis of pseudouridine from uracil in tRNAsrs177542821.4414.97E-051187622650IntergenicAlso shows nominal association (P < 0.05) in quantitative GWAS by Lasky-Su et al. (2008b)rs71872230.44585.21E-051681015234Intergenic, within 203 kb upstream from CDH13Encodes cadherin 13, a member of the cadherin superfamily. The encoded protein is a calcium-dependent cell–cell adhesion glycoprotein. This particular cadherin is a putative mediator of cell–cell interaction in the heart and may act as a negative regulator of neural cell growth. Lies within the only significant linkage region for ADHD as determined in met-analysis (Zhou et al. 2008c). Has earlier shown association with metamphetamine dependence in GWAS (Uhl et al. 2008a). Gene is also found in GWAS in schizophrenia with P values at 10−4 (Sullivan et al. 2008) and shows CNVs potentially related to autism (Christian et al. 2008)Most significant finding in quantitative
