linkage region from a primary study in adult ADHD (Romanos et al. 2008) and the ADHD linkage meta-analysis (Zhou et al. 2008c)rs76576081.3562.96E-054168390756Intron of SPOCK3Encodes a member of a novel Ca(2+)-binding proteoglycan family, a component of the extracellular matrix, high expression in brain, especially the caudate nucleusrs96086171.3762.96E-052226236244IntergenicLies within schizophrenia linkage region reported in meta-analysis (Lewis et al. 2003)rs66577490.66432.99E-051212643136Intron of PTPN14Encodes a brain-expressed member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Gene shows P values at 10−4 in GWAS in bipolar disorder (Sklar et al. 2008)rs177225141.6483.14E-051389511946IntergenicSite is known for CNVs.Also shows nominal association (P < 0.05) in quantitative GWAS by Lasky-Su et al. (2008b)rs14273240.72363.50E-051458434446Intergenicrs112210641.4393.89E-0511127192523IntergenicClose to schizophrenia linkage region reported in meta-analysis (Lewis et al. 2003)Also shows nominal association (P < 0.05) in quantitative GWAS by Lasky-Su et al. (2008b)rs69198570.7494.79E-056137182147Within 5 kb upstream of PEX7 and 27 kb downstream of MAP3K5PEX7 encodes peroxisomal biogenesis factor 7, the cytosolic receptor for a set of peroxisomal matrix enzymes. MAP3K5 encodes a member of the MAPK pathway, that might be involved in apoptotic regulation in the brainAlso shows nominal association (P < 0.05)
