Third, the DM may also be interpreted as predicting that heavier drinkers would respond more than lighter drinkers to the stimulant effects of alcohol on the ascending limb of the BAC curve in particular. We found some support for this proposition in that, relative to lighter drinkers, heavier drinkers on average reported moderately and significantly greater stimulation on the ascending limb, g = 0.53 (95% CI: 0.15, 0.91), whereas the stimulation effect on the descending limb was small-to-moderate and not significantly different from zero, g = 0.34 (95% CI: −0.13, 0.80). In addition, there was moderate between-study heterogeneity in stimulation differences on the ascending and descending limbs, although heterogeneity on the descending limb did not reach significance, Qwithin(7) = 16.44, p = .02, I2 = 57.43 and Qwithin(5) = 10.37, p = .07, I2 = 51.76, respectively. The fail-safe N for differences in stimulation on the ascending limb was 28. As shown in Table 4, heavier drinkers reported moderately and significantly less sedation in samples assessed on the ascending limb and in samples assessed on the descending limb, and there
