for differences in stimulation on the ascending limb was 28. As shown in Table 4, heavier drinkers reported moderately and significantly less sedation in samples assessed on the ascending limb and in samples assessed on the descending limb, and there was no heterogeneity across studies, Qwithin(6) = 8.33, p = .22, I2 = 27.94, and Qwithin(3) = 0.94, p = .82, I2 = 0.00, respectively. Fail-safe Ns for sedation on the ascending and descending limbs were 26 and 2, respectively.