In this paper, we report our recent improvements of COXPRESdb, in terms of two refinement points. For the first point, we newly prepared RNAseq-based gene coexpression data for three species (human, mouse and fly), and increased the number of microarray experiments to nine species. Increased number of coexpressed gene pairs supported by multiple platforms indicates steady improvement of the coexpression data set. For the second point, we refined the data assessment procedures for each coexpressed gene list, which now uses more accurate P-values based on platform-specific null distribution. These developments minimize pseudo-predictions for directly associated genes, thus expanding the utility of coexpression data for designing new experiments and discussing experimental results.
