Chunk #3 — 1. Introduction

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Variation in the ADH1B proximal promoter affects expression.

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Two SNPs in the ADH1B promoter region, rs1229982 and rs1159918, are associated with alcohol dependence defined by meeting both DSM-IIIR criteria for alcohol dependence plus criteria for Feighner definite alcoholism [25]. We tested the effect of the two polymorphisms and others in the ADH1B promoter region on promoter activity.