We report here a genome-wide meta-analysis of PAU in 435,563 individuals of European ancestry from the MVP, PGC, and UKB datasets. MVP is a mega-biobank that has enrolled >750,000 subjects (for whom genotype data on 313,977 subjects were used in this study), with rich phenotype data assessed by questionnaires and from the EHR. Currently, MVP is the largest single cohort available with diagnostic information on AUD [3, 6]. PGC is a collaborative consortium that has led the effort to collect smaller cohorts with DSM-IV AD [2]. UKB is a population-level cohort with the largest available sample with AUDIT-P data [4].
