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Chunk #21 — Results — Joint Analysis of PAU and DrnkWk Using MTAG

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Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits.
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The MTAG analysis also increased the power for the functional enrichment analysis. MAGMA gene set analysis for PAU after MTAG analysis detected 10 enriched Gene Ontology terms, including ‘regulation of nervous system development’ (pBonferroni = 8.80 × 10−4), ‘neurogenesis’ (pBonferroni = 0.010), and ‘synapse’ (pBonferroni = 0.046) (Supplementary Table 16).