We conducted a joint analysis of PAU and DrnkWk using MTAG, which can increase the power for each trait without introducing bias from sample overlap [10]. MTAG analysis increased the GWAS-equivalent sample size (nEq) for PAU to 514,790, i.e., a 71.1% increase from the original effective sample size (nE = 300,789, n = 435,563). In this analysis, we observed an increase in the number of independent variants for PAU to 119, 76 of which were conditionally independent (Supplementary Figure 6a, Supplementary Table 14). For DrnkWk, the MTAG analysis increased the nEq to 612,968 from 537,352, which yielded 141 independent variants, 86 of which were conditionally independent (Supplementary Figure 6b, Supplementary Table 15).
