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Chunk #27 — Results — Gene set enrichment analysis of T2D associations in mitochondria-related gene sets

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Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits.
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Finally, we applied MAGENTA to 966 nuclear-encoded human mitochondrial genes taken from the MitoCarta compendium (∼85% of all mitochondrial genes; see Materials and Methods) [22]. We did not observe significant enrichment of T2D associations for the whole set of mitochondrial genes either (Table 3; nominal = 0.91). A more detailed view of the mitochondrial gene score distribution is shown in Figure S7C (see Table S12 for a list of all mitochondrial gene association p-values).