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Chunk #26 — Results — Gene set enrichment analysis of T2D associations in mitochondria-related gene sets

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Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits.
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Next, we tested for enrichment of T2D associations in a set of 91 autosomal OXPHOS genes (highlighted in the full list of mitochondrial gene scores in Table S12). Using MAGENTA, no significant enrichment of T2D associations was found among the 91 OXPHOS genes analyzed (Table 3; = 0.47). A plot of the OXPHOS T2D gene scores against an expected distribution of gene scores is shown in Figure S7B.