The symbols refer to sources diagramed in Figure 1. MuAc, MuPref and HuAlc refer to presence in the microarray studies mentioned above. HuAddChip are selected genes from human association studies on alcohol dependence using the "addiction chip" designed by David Goldman and colleagues at the National Institute on Alcohol Abuse and Alcoholism (NIAAA) [19]. HuLink refers to genes contained within linkage regions that have been implicated multiple times across human studies of alcohol-related phenotypes on chromosomes 1, 4, and 7 [16-18]. The region on chromosome 1 ranges from D1S1613 at 64,007,000 bp to D1S2624 at 154,898,000 bp (according to HapMap build 36) and encompasses a variety of overlapping linkage signals to alcohol-related phenotypes, including alcohol dependence, heavy drinking, sensitivity to alcohol, and tolerance, across a number of samples [17,18,33-38]. The chromosome 4 region ranges from D4S2382 at 39,727,200 bp to D4S1615 at 128,429,200 bp and encompasses linkage peaks from four independent samples [16,18,39-42]. The chromosome 7 region ranged from D7S691 at 41,996,200 bp to D7S1817 at 109,026,000 bp and constitutes the strongest linkage region in the Collaborative Study of the
