Chunk #54 — Discussion

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Designing genome-wide association studies: sample size, power, imputation, and the choice of genotyping chip.

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As would be expected, power is also lower for all chips for samples which match the patterns of LD seen in the Yoruba HapMap sample, and again the relative ordering of chips changes in this setting. It is not yet clear how well the results for the Yoruba would extend to other African populations.