Chunk #53 — Discussion

Source

Designing genome-wide association studies: sample size, power, imputation, and the choice of genotyping chip.

Embedded

yes

Text

When the causal SNP is rare (MAF<10%), all chips have low power unless its effect is large and sample sizes are large. This conclusion would hold even if the chip directly genotyped the causal SNP. The relative ordering of different chips, on the basis of power, also changes in this context.