All data are publically available following the completion of a data use agreement that can be completed through the RUSH University ADC (https://www.radc.rush.edu/requests/additionalForms.htm/) or the Synapse platform (https://www.synapse.org/#!Synapse:syn2954404). The ROS and MAP cohorts have useful features that allow the data generated from their subjects to be repurposed for many different analyses and to render results relevant to the population of older individuals. Most importantly, all subjects are community-dwelling without known dementia at the time of enrollment. All testing is performed in the participants’ homes, and the only inclusion criteria are age and willingness to sign the informed consent and Anatomical Gift Act. Thus, participants capture the full spectrum of phenotypes found in an aging human population. Further, both ROS and MAP include longitudinal rigorous clinical, functional, neuropsychologic and magnetic resonance imaging characterization of participants while they are alive, as well as a structured clinical and quantitative neuropathologic assessment at autopsy. The application of standard clinical scales to the collected data provides both syndromic diagnoses and semi-quantitative measures such as the many cognitive function tests that allow the comparison of results
