Rs2236196 in CHRNA4 is the most significant not only in the 2-df full sample test, but also in the EA sample. Only one CHRNA4 SNP, rs2229959, shows any hint of association in AAs with an odds ratio of 0.82 (0.66-1.02) and p = 0.08; thus it has an odds ratio opposite that in all the EAs (OR = 1.33 (1.09-1.62), p = 0.004).
