The next group of SNPs in Table 3 all lie upstream of CHRNB3-CHRNA6 (rs13277254, rs10958726, rs1955186, rs13277524). They all have p-values ≤ 0.003 and their association evidence is improved when analyzing all EAs compared to the original EA sample (e.g. for rs13277254, OR = 0.76 (0.66-0.89) p = 0.00063 in all EAs; OR = 0.78 (0.64-0.91), p = 0.0031 in the original EAs). However, there is no evidence for association of these SNPs in AAs, with point estimates for the ORs ranging from 0.9 to 1.01 and p-values from 0.33-0.94. A different CHRNB3 SNP, rs4952, though less common (minor allele frequency < 5%), is of interest because it has a strong, similar odds ratio in EAs and in AAs (0.42 (0.65 (0.47-0.91), p = 0.01 in EAs, 0.16-1.08), p = 0.07) in AAs).
