Chunk #16 — Results — Description of discovery and replication samples in relation to smoking behaviors — Discovery sample

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Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence.

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In total, 8,842 subjects with 352,228 SNPs each were analyzed. The average ages of the participants were 52.22 ± 8.91 (SD) years: 51.78 ± 8.78 for men and 52.61 ± 9.01 for women. Female participants were 52.7% (N = 4,659) of all subjects, however, only 4.93% were smokers, being categorized as former (1.34%), occasional (1.29%), or habitual (2.30%) smokers. In contrast, 80.62% of the male participants smoked. Among them, 31.05% were former smokers, 4.78% occasional smokers, and 44.79% habitual smokers. For habitual smokers, the average number of cigarettes smoked per day (CPD) was 19.51 ± 8.74 for male and 11.93 ± 7.28 for female smokers.