v105975 also lessened ethanol sensitivity in sedation assays without having a major effect on internal ethanol concentrations (Figure 7C and E). Nervous system expression of Clic RNAi v105975 also decreased ethanol sensitivity without substantively impacting internal ethanol concentrations (Figure 7D and F). Therefore, decreased function of Clic alters ethanol sensitivity measured in sedation experiments. Importantly, these behavioral changes are independent of mini-w because ethanol sensitivity is not greatly influenced by mini-w or endogenous w in sedation assays (Figures 4–6).
