As hypothesized, we found that network strength, in LECN, though not in the RECN, was lower in ALC than HC and negatively correlated with disorder severity. Within the LECN, we examined the edges, or the pairwise temporal correlations between ROIs to identify the nodes that seemed to drive this relationship. We found negative associations between both failed control and AUDIT scores and the connectivity between the parietal, DLPFC, MFG and caudate nodes suggesting poor function of this control network. This is consistent with studies that have reported negative associations between white matter integrity in tracts connecting frontal and parietal regions and substance use (Pfefferbaum et al., 2009, Schulte et al., 2010), validating the important relationship between these structures and impaired control in ALC. Of interest, a recent study of stimulant dependent individuals (SDI), a majority of whom was also dependent on alcohol, found a lateralized differentiation of the ECNs. As resting state amplitude in the left DLPFC correlated with approach behaviors, the authors suggested that the LECN may be involved in maintaining a bias toward seeking and taking drugs, rather
