The quantile-quantile (q-q) plot of association results (Figure S2, Panel A) and the genomic inflation factor value (λ=1.01) indicate an absence of test statistic inflation. The strongest association involves a cluster of chromosome 1 SNPs (Manhattan plot, Figure S2, Panel B). The six most highly associated, all located in CNIH3 (Table 1), are in moderate to high LD (r2=0.35–0.97); conditional analyses suggest they represent a single association signal (Figure S2, Panel C). The association reached genome-wide significance (GWS) for rs1436175 [p=2.72 E-8; OR 0.50 (0.39–0.64)] with the risk allele halving the likelihood of progression to ODE.
